Objective To explore the preventive and therapeutic effects of gingerol on lipopolysaccharide （LPS）⁃ induced procoagulant and fibrinolytic inhibition in acute respiratory distress syndrome（ARDS）rats and its possible mechanism. Methods Male SD rats were randomly divided into control group，LPS group and different dose of gingerol group（10 m/kg，20 m/kg，30 m/kg）. The ARDS model of rats was induced by LPS intratracheal atomization inhalation and treated by intraperitoneal injection of different doses of gingerol. The pathological changes of rat lung were observed by H&E staining，and the degree of lung injury was evaluated. The wet/dry ratio of lung tissue was calculated to evaluate pulmonary edema；the mRNA expression of tissue factor（TF），and plasminogen activator inhibitor⁃1（PAI⁃1） was detected by real⁃time fluorescence quantitative reverse transcription polymerase chain reaction；western blot was used to detect the protein expressions of TF，PAI⁃1 and nuclear factor⁃ κB p65（p65），phosphorylation of p65（p⁃p65），inhibitor of nuclear factor⁃κB kinase（IKKβ）and phos⁃ phorylation of IKKβ（p⁃IKKβ）in lung tissues. Results Compared with those in the control group，the pulmonary tissues in the model group were seen with damaged alveolar structures，widened alveolar septa，increased inflam⁃ matory cell infiltration and increased lung injury score. The mRNA level of TF and PAI⁃1 in lung tissue was signifi⁃ cantly increased，and the protein expression level of TF，PAI⁃1，p65 and IKK in lung tissue of group A was signifi⁃ cantly increased. Compared to those in the model group，lung tissues in mice of gingerol groups were seen with decreased deconstruction，narrowed alveolar septa，decreased inflammtory cells infiltration and declined lung injury score. In gingerol groups，pulmonary expressions of TF，PAI⁃1，p⁃p65，and p⁃IKKβ protein were all decreased or declined，among which the changes of above indexes in mice with high dose gingerol were more obvious than those in mice with medium and low dose. Conclusion Gingerol dose⁃dependently ameliorates alveolar hypercoagulation and fibrinolytic inhibition and reduces lung injury for LPS⁃induced ARDS in rat，and the effects might be associated with the inactivation of NF⁃ κ B signal pathway.